Alkaline Phosphatase (ALPL) polyclonal (N-term), anti-human, mouse
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In stock
SKU
AC-AP1474a
Catalog Number: AC-AP1474a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB13414
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB13414
Applications: WB
Datasheet
Request Information
Background:
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The genes for the first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. This protein is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.
Other Names:
Alkaline phosphatase, tissue-nonspecific isozyme, AP-TNAP, TNSALP, Alkaline phosphatase liver/bone/kidney isozyme, ALPL
Target/Specificity:
This Alkaline Phosphatase (ALPL) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-32 amino acids from the N-terminal region of human Alkaline Phosphatase (ALPL).
Antigen Region:
3-32
Antigen Type: Synthetic Peptide
Gene Name: ALPL {ECO:0000303|PubMed:8406453, ECO:0000312|HGNC:HGNC:438}
Gene ID: 249
Primary Accession: P05186
NCBI Accession: NP_000469.3;NP_001120973.2;NP_001170991.1
Other Accession: P09487
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The genes for the first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. This protein is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.
Other Names:
Alkaline phosphatase, tissue-nonspecific isozyme, AP-TNAP, TNSALP, Alkaline phosphatase liver/bone/kidney isozyme, ALPL
Target/Specificity:
This Alkaline Phosphatase (ALPL) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-32 amino acids from the N-terminal region of human Alkaline Phosphatase (ALPL).
Antigen Region:
3-32
Antigen Type: Synthetic Peptide
Gene Name: ALPL {ECO:0000303|PubMed:8406453, ECO:0000312|HGNC:HGNC:438}
Gene ID: 249
Primary Accession: P05186
NCBI Accession: NP_000469.3;NP_001120973.2;NP_001170991.1
Other Accession: P09487
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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