Alkaline Phosphatase (Intestinal) (clone ALPI/597), anti-human, bovine
€0.00
In stock
SKU
ARP-24-248-MSM2
Catalog Number: 24-248-MSM2
Size: 100 µl, 0.5 ml, 1 ml
Isotype: Mouse IgG1, kappa
Size: 100 µl, 0.5 ml, 1 ml
Isotype: Mouse IgG1, kappa
Decription:
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Synonyms: Alkaline phosphatase, germ cell, Alkaline phosphatase, testicular and thymus, Akp2, Alkaline phosphatase intestinal, Alkaline phosphatase liver/bone/kidney, Alkaline phosphatase placental, Alkaline phosphatase placental like 2, Alkaline phosphatase, tissue-nonspecific, ALPG, ALPI, ALPL, ALPP, ALPPL, ALPPL2, AP TNAP, Germ cell alkaline phosphatase, HOPS, Intestinal alkaline phosphatase (IAP), Kasahara isozyme, Nagao isozyme, PLAP, PLAP like, Regan isozyme, Testicular and thymus alkaline phosphatase, Tissue non-specific alkaline phosphatase, Tissue nonspecific ALP (TNAP or TNSALP)
Clone: ALPI/597
Isotype: Mouse IgG1, kappa
Immunogen: Recombinant human ALP1 protein
Reactivity: human and cow. Others not known.
Form: Purified, in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Applications: Flow Cytometry (5-10ul/million cells in 0.1ml)
Immunofluorescence (1:50-1:100)
Immunohistology (Formalin-fixed) (1:50-1:100 for 30 min at Room Temp)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.
Reactivity: Intestine
Concentration: 0.2mg/ml
Storage: Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Synonyms: Alkaline phosphatase, germ cell, Alkaline phosphatase, testicular and thymus, Akp2, Alkaline phosphatase intestinal, Alkaline phosphatase liver/bone/kidney, Alkaline phosphatase placental, Alkaline phosphatase placental like 2, Alkaline phosphatase, tissue-nonspecific, ALPG, ALPI, ALPL, ALPP, ALPPL, ALPPL2, AP TNAP, Germ cell alkaline phosphatase, HOPS, Intestinal alkaline phosphatase (IAP), Kasahara isozyme, Nagao isozyme, PLAP, PLAP like, Regan isozyme, Testicular and thymus alkaline phosphatase, Tissue non-specific alkaline phosphatase, Tissue nonspecific ALP (TNAP or TNSALP)
Clone: ALPI/597
Isotype: Mouse IgG1, kappa
Immunogen: Recombinant human ALP1 protein
Reactivity: human and cow. Others not known.
Form: Purified, in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Applications: Flow Cytometry (5-10ul/million cells in 0.1ml)
Immunofluorescence (1:50-1:100)
Immunohistology (Formalin-fixed) (1:50-1:100 for 30 min at Room Temp)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.
Reactivity: Intestine
Concentration: 0.2mg/ml
Storage: Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
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