Alkaline Phosphatase polyclonal, anti-rat, mouse

Quantity: 100 µg

Background:
Alkaline phosphatase, tissue-nonspecific isozyme is an enzyme that in humans is encoded by the ALPL gene. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney(tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. Liver/bone/kidney alkaline phosphatase, also known as tissue-nonspecific alkaline phosphatase, acts physiologically as a lipid-anchored phosphoethanolamine(PEA) and pyridoxal-5-prime-phosphate(PLP) ectophosphatase Mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects.

Description:
Rabbit IgG polyclonal antibody for Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) detection. Tested with WB, IHC-P in Mouse, Rat.

Synonyms:
Akp2 antibody, Alkaline phosphatase intestinal antibody, Alkaline phosphatase intestinal precursor antibody, Alkaline phosphatase liver/bone/kidney antibody, Alkaline phosphatase placental antibody, Alkaline phosphatase placental like 2 antibody, Alkaline phosphatase placental like antibody, Alkaline phosphatase placental type antibody, Alkaline phosphomonoesterase antibody, ALP 1 antibody, ALP antibody, ALP I antibody, ALP L antibody, ALP P antibody, ALPG antibody, ALPI antibody, ALPL antibody, ALPP antibody, ALPPL antibody, ALPPL2 antibody, AP TNAP antibody, FLJ40094 antibody, GCAP antibody, Germ cell alkaline phosphatase antibody, Glycerophosphatase antibody, HOPS antibody, IAP antibody, Intestinal alkaline phosphatase antibody, Kasahara isozyme antibody, Nagao isozyme antibody, OTTHUMP00000164357 antibody, Placental alkaline phosphatase antibody, Placental like alkaline phosphatase antibody, PLAP 1 antibody, PLAP antibody, PLAP like antibody, Regan isozyme antibody, Testicular and thymus alkaline phosphatase antibody, Tissue non specific alkaline phosphatase antibody, Tissue nonspecific ALP antibody, TNAP antibody, TNSALP antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of rat Alkaline Phosphatase(18-32aa, FVPEKEKDPSYWRQQ), different from the related mouse sequence by one amino acid.A synthetic peptide corresponding to a sequence at the N-terminus of rat Alkaline Phosphatase(18-32aa, FVPEKEKDPSYWRQQ), different from the related mouse sequence by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: rat.
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.