ALOX5 Polyclonal Antibody

Background:
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Cardiovascular, Metabolism, Signal Transduction

Synonyms:
5 LO, 5 LOX, 5-lipoxygenase, 5-LO, 5-LOX, 5LOX, 5LPG, ALOX 5, Alox5, Arachidonate 5 lipoxygenase, Arachidonate 5-lipoxygenase, arachidonic 5-lipoxygenase alpha-10 isoform, arachidonic 5-lipoxygenase delta-10-13 isoform, arachidonic 5-lipoxygenase delta-13 isoform, arachidonic 5-lipoxygenase delta-p10 isoform, Arachidonic acid 5 lipoxygenase, Leukotriene A4 synthase, LOG 5, LOG5, LOX5, MGC163204

Immunogen: Recombinant protein of human ALOX5

Swissprot: P09917
Gene Accession: BC130332

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.7 mg/mL
Dilution: IHC 1:50-1:150

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-8885/sc-8886/sc-20785