Alpha-1 Antitrypsin polyclonal biotin, anti-human, mouse, rat, rabbit, dog, pig, sheep, bovine

Protein Family: Enzymes, Peptidases

Pathway and Disease: Immune System; Folding, Sorting, and Degradation

Description:
AAT (Alpha-1-antitrypsin) is an inhibitor of serine proteases. Although AAT's primary target is elastase, the enzyme has also a moderate affinity for plasmin and thrombin. AAT inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. AAT deficiency is related to emphysema and liver disease.

Alternate Names: Alpha-1-antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, SERPINA1, AAT, PI

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:200-500

Accession No.: P01009

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human AAT.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 10 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed 6 months from the date of shipment.