alpha 2a Adrenergic Receptor polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
The alpha-2A adrenergic receptor, also known as ADRA2A denotes the human gene encoding it. This gene is mapped to 10q25.2. Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Description:
Rabbit IgG polyclonal antibody for Alpha-2A adrenergic receptor (ADRA2A) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
ADA2A_HUMAN antibody, ADRA2 antibody, ADRA2A antibody, ADRA2R antibody, ADRAR antibody, Adrenergic alpha 2A receptor antibody, Alpha 2 adrenergic receptor subtype C10 antibody, Alpha 2A adrenergic receptor antibody, Alpha 2AAR subtype C10 antibody, Alpha-2 adrenergic receptor subtype C10 antibody, alpha-2-adrenergic receptor, platelet type antibody, Alpha-2A adrenergic receptor antibody, Alpha-2A adrenoceptor antibody, Alpha-2A adrenoreceptor antibody, Alpha-2AAR antibody, ALPHA2AAR antibody, OTTHUMP00000058849 antibody, ZNF32 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human alpha 2a Adrenergic Receptor(213-228aa ILVYVRIYQIAKRRTR), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human.
Predicted to work with: mouse, rat.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.