alpha 5 beta 1 Integrin (Volociximab) (clone ), anti-human antibody

Background:
The antibody binds specifically to a5ß1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The a5ß1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.

Other Names:
Fibronectin receptor, CD49 antigen-like family member E, Integrin alpha-F, VLA-5, CD49e

Primary Accession: P08648

Gene Name: ITGA5

Gene ID: 3678