AMACR Polyclonal Antibody

Background:
This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene.

Research Area: Cell Biology, Metabolism, Signal Transduction

Synonyms:
AMACR, AMACRD, CBAS4, P504S, RACE, RM

Immunogen: Recombinant fusion protein of human AMACR (NP_976316.1).

Swissprot: Q9UHK6
Gene ID: 23600

Calculated MW: 22 kDa/25 kDa/42 kDa/43 kDa
Observed MW: 43 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.