AMOTL2 Picoband polyclonal, anti-human, mouse, rat
€455.00
In stock
SKU
AC-ABO13056
Catalog Number: AC-ABO13056
Size: 100 µg
Isotype: Rabbit IgG
Applications: WB, E
Datasheet
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Size: 100 µg
Isotype: Rabbit IgG
Applications: WB, E
Datasheet
Request Information
Description: Rabbit IgG polyclonal antibody for AMOTL2 detection. Tested with WB, Direct ELISA in Human;Mouse;Rat.
Protein Function:
Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
Other Names: Angiomotin-like protein 2, Leman coiled-coil protein, LCCP, AMOTL2, KIAA0989
Subcellular Localization: Recycling endosome.
Gene ID: 51421
Immunogen: E. coli-derived human AMOTL2 recombinant protein (Position: A401-Q480).
Calculated MW: 85764
Format: Lyophilized
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Storage: At -20˚C; for one year. After reconstitution, at 4˚C; for one month. It can also be aliquotted and stored frozen at -20˚C; for a longer time. Avoid repeated freezing and thawing.
Protein Function:
Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
Other Names: Angiomotin-like protein 2, Leman coiled-coil protein, LCCP, AMOTL2, KIAA0989
Subcellular Localization: Recycling endosome.
Gene ID: 51421
Immunogen: E. coli-derived human AMOTL2 recombinant protein (Position: A401-Q480).
Calculated MW: 85764
Format: Lyophilized
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Storage: At -20˚C; for one year. After reconstitution, at 4˚C; for one month. It can also be aliquotted and stored frozen at -20˚C; for a longer time. Avoid repeated freezing and thawing.
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