AMP Deaminase, Isoform E (AMPD3) (Erythroid Marker) (clone AMPD3/901 ), anti-human
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In stock
SKU
AC-AH11326
Catalog Number: AC-AH11326
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: AMPD3/901
Applications: IHC-F, IF, FC, ICC
Datasheet
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Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: AMPD3/901
Applications: IHC-F, IF, FC, ICC
Datasheet
Request Information
Background:
It recognizes a protein of ~90kDa, which is identified as Adenosine Monophosphate Deaminase, isoform E (AMPD3). It has 767 amino acids and is assigned an EC 3.5.4.6. It is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. AMPD3 gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. This MAb shows reactivity with cells of the erythroid lineage at all stages of maturation in the peripheral blood, bone marrow, and fetal liver. Non-erythroid lineages are negative by flow cytometry. This MAb is useful in the diagnosis of erythroleukemia, identification of bone marrow erythroid precursors, gating erythroid nucleated precursor cells from malignant cells in bone marrow specimens.
Other Names:
AMP deaminase 3, 3.5.4.6, AMP deaminase isoform E, Erythrocyte AMP deaminase, AMPD3
Gene Name: AMPD3 (HGNC:470)
Gene ID: 272
Primary Accession: Q01432
Other Accession: 272, 501890
It recognizes a protein of ~90kDa, which is identified as Adenosine Monophosphate Deaminase, isoform E (AMPD3). It has 767 amino acids and is assigned an EC 3.5.4.6. It is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. AMPD3 gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. This MAb shows reactivity with cells of the erythroid lineage at all stages of maturation in the peripheral blood, bone marrow, and fetal liver. Non-erythroid lineages are negative by flow cytometry. This MAb is useful in the diagnosis of erythroleukemia, identification of bone marrow erythroid precursors, gating erythroid nucleated precursor cells from malignant cells in bone marrow specimens.
Other Names:
AMP deaminase 3, 3.5.4.6, AMP deaminase isoform E, Erythrocyte AMP deaminase, AMPD3
Gene Name: AMPD3 (HGNC:470)
Gene ID: 272
Primary Accession: Q01432
Other Accession: 272, 501890
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