Amphiphysin II Polyclonal Antibody

Background:
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Microbiology

Synonyms:
AMPH 2, AMPH2, Amphiphysin 2, Amphiphysin II, Amphiphysin like protein, amphiphysin-like, Amphiphysin-like protein, AMPHL, Bin1, BIN1, Box Dependant MYC Interacting Protein 1, Box-dependent myc-interacting protein 1, Bridging integrator 1, DKFZp547F068, MGC10367, MGC105358, Myc box dependent interacting protein 1, Myc box-dependent-interacting protein 1, SH3P9

Immunogen: Recombinant protein of human BIN1

Swissprot: O00499
Gene Accession: BC004101

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.1 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-8534/sc-30099