AMPKβ 1 (clone 1A7-E11-E9), anti-human, mouse, rat, monkey

Background:
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK).AMPK is a heterotrimer consisting of an alpha catalytic subunit,and non-catalytic beta and gamma subunits.AMPK is an important energy-sensing enzyme that monitors cellular energy status.In response to cellular metabolic stresses,AMPK is activated,and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR),key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol.This subunit may be a positive regulator of AMPK activity.The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.[provided by RefSeq,Jul 2008]

Synonyms: AMPK, HAMPKb

Cellular Location: Cytosol Nucleus

Immunogen:
Purified recombinant human AMPK beta 1 protein fragments expressed in E.coli.

Gene Symbol: AMPKβ 1

Gene ID: 5564

Swiss prot: Q9Y478

Calculated MW: 38kDa

Recommended dilution:
WB 1:1000, IHC 1:100

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.