AMPKβ polyclonal, anti-human, mouse antibody
€355.00
In stock
SKU
AC-ABV10085-100
Catalog Number: AC-ABV10085-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB, IHC, E
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB, IHC, E
Datasheet
Request Information
Background:
AMPK beta-1 chain is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Other Names:
AMPK, 5'-AMP-activated protein kinase, beta-1 subunit, AMP activated protein kinase beta-1 subunit, AMPK beta-1 chain, AMPKb
Primary Accession: Q9Y478
Gene Name: PRKAB1
Gene ID: 5564
Concentration (mg/ml): 0.25 mg/ml
AMPK beta-1 chain is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Other Names:
AMPK, 5'-AMP-activated protein kinase, beta-1 subunit, AMP activated protein kinase beta-1 subunit, AMPK beta-1 chain, AMPKb
Primary Accession: Q9Y478
Gene Name: PRKAB1
Gene ID: 5564
Concentration (mg/ml): 0.25 mg/ml
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