Amylin polyclonal, anti-human, rat, cat, pig, guinea pig

Quantity: 100 µl

Background:
Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.

Synonyms:
IAPP, DAP, IAP

Isotype: Rabbit Polyclonal

Immunogen:
Amylin

Form: Serum containing 0.1% sodium azide

Specificity:
Amylin

Reactivity: human, rat, cat, pig, guinea pig

Applications: Immunohistochemistry, suitable in frozen and paraffin sections, Immunofluorescence

Working DIlution: 1:40 to 1:75 using PAP; 1:15 to 1:25 with FITC in immunofluorescence

Positive Control:
Formalin-fixed paraffin and frozen sections of human or rat pancreas

Storage: 2-8C for immediate use, or at -20C (aliquot)

References:
- Mulder H et al. (1997) Peptides 18(6): 771-783
- Mulder H et al. (1995) Diabetologia 38: 395-402