Amyloid beta precursor protein polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Amyloid precursor protein(APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formation, neural plasticity and iron export. APP is best known and most commonly studied as the precursor molecule whose proteolysis generates beta amyloid(Abeta), a 39- to 42-amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. APP undergoes posttranslational proteolytic processing by alpha-, beta-, and gamma-secretases. Alpha-secretase generates soluble amyloid protein, while beta- and gamma-secretases generate APP components with amyloidogenic features. These 2 processing pathways are mutually exclusive.

Description:
Rabbit IgG polyclonal antibody for Amyloid beta A4 protein (APP) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
A4 amyloid protein antibody, A4 antibody, A4_HUMAN antibody, AAA antibody, ABETA antibody, ABPP antibody, AD 1 antibody, AD1 antibody, AICD-50 antibody, AICD-57 antibody, AICD-59 antibody, AID(50) antibody, AID(57) antibody, AID(59) antibody, Alzheimer Disease 1 antibody, Alzheimer disease amyloid protein antibody, Alzheimer's Disease Amyloid Protein antibody, Amyloid beta(A4) precursor protein antibody, Amyloid beta A4 protein antibody, Amyloid Beta A4 Protein Precursor Isoform A antibody, Amyloid beta A4 protein precursor isoform b antibody, Amyloid beta A4 protein precursor isoform c antibody, Amyloid Beta Peptide antibody, Amyloid beta protein antibody, Amyloid intracellular domain 50 antibody, Amyloid intracellular domain 57 antibody, Amyloid intracellular domain 59 antibody, Amyloid Of Aging And Alzheimer Disease antibody, APP antibody, APPI antibody, Beta amyloid peptide antibody, Beta-APP40 antibody, Beta-APP42 antibody, C31 antibody, Cerebal Vascular Amyloid Peptide antibody, Cerebral vascular amyloid peptide antibody, CTFgamma antibody, CVAP antibody, Gamma-CTF(50) antibody, Gamma-CTF(57) antibody, Gamma-CTF(59) antibody, Human mRNA For Amyloid A4 Precursor Of Alzheimer's Disease antibody, Peptidase nexin II antibody, peptidase nexin-II antibody, PN 2 antibody, PN II antibody, PN-II antibody, PN2 antibody, PNII antibody, PREA4 antibody, Protease Nexin II antibody, Protease nexin-II antibody, S-APP-alpha antibody, S-APP-beta antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human Amyloid beta precursor protein(18-32aa EVPTDGNAGLLAEPQ), identical to the related mouse and rat sequences.A synthetic peptide corresponding to a sequence at the N-terminus of human Amyloid beta precursor protein(18-32aa EVPTDGNAGLLAEPQ), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat.
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.