ANAPC15 Polyclonal Antibody

Background:
ANAPC15 is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, it plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating to the responsiveness of the spindle assembly checkpoint. It is also required for degradation of CDC20.

Research Area: Cell Biology

Synonyms:
ANAPC15, Anaphase-promoting complex subunit 15, C11orf51, CK051, HSPC020, Uncharacterized protein C11orf51

Immunogen: Synthetic peptide of human ANAPC15

Swissprot: P60006
Gene Accession: NP054761

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.2 mg/mL
Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.