Androgen receptor, anti-human
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In stock
SKU
AC-AP22418a
Catalog Number: AC-AP22418a
Size: 50 µl, 200 µl
Isotype: Rabbit Ig
Clone Name: R03657
Applications: WB
Datasheet
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Size: 50 µl, 200 µl
Isotype: Rabbit Ig
Clone Name: R03657
Applications: WB
Datasheet
Request Information
Background:
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Other Names:
Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4
Target/Specificity:
This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from human.
Antigen Type: Recombinant Protein
Gene Name: AR
Gene ID: 367
Primary Accession: P10275
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Other Names:
Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4
Target/Specificity:
This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from human.
Antigen Type: Recombinant Protein
Gene Name: AR
Gene ID: 367
Primary Accession: P10275
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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