Androgen Receptor polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
The AR(androgen receptor) gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The AR gene is mapped to Xq12. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy(Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity(CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

Description:
Rabbit IgG polyclonal antibody for Androgen receptor (AR) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.

Synonyms:
AIS antibody, ANDR_HUMAN antibody, Androgen receptor(dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) antibody, Androgen receptor antibody, AR antibody, DHTR antibody, Dihydro Testosterone Receptor antibody, Dihydrotestosterone receptor antibody, HUMARA antibody, HYSP1 antibody, KD antibody, NR3C4 antibody, Nuclear receptor subfamily 3 group C member 4 antibody, SBMA antibody, SMAX1 antibody, Spinal and bulbar muscular atrophy antibody, TFM antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Androgen Receptor(822-838aa LKNQKFFDELRMNYIKE), identical to the related rat and mouse sequences.A synthetic peptide corresponding to a sequence at the C-terminus of human Androgen Receptor(822-838aa LKNQKFFDELRMNYIKE), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P, ICC

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.