Angiopoietin 1 polyclonal, anti-human, rat

Background:
Tie-1 and Tie-2 (also designated Tek) are novel cell surface receptor tyrosine kinases. The extracellular domain of Tie-1 has an unusual multidomain structure consisting of a cluster of three epidermal growth factor homology motifs localized between two immunoglobulin-like loops, which are followed by three fibronectin type III repeats next to the transmembrane region. Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2. Preliminary biochemical analyses of Ang-1 reveal a potential fibrinogen-like domain at the carboxy terminus and coiled-coil regions in the amino terminus. Ang-1 is an angiogenic factor that is thought to be involved in endothelial development. A related protein, angiopoietin-2 (Ang-2), has been identified as a naturally occurring antagonist of Ang-1 activation of Tie-2. In adult tissue, Ang-2 expression seems to be restricted to sites of vascular remodeling.

Alternative Name:
ANG-1, ANGPT1, AGP 1, AGP1, AGPT, ANG 1, ANG, ANG-1, ANG1, Angiopoietin-1, Angiopoietin1, ANGP1, ANGPT 1, Angpt1, KIAA0003, OTTHUMP00000227592, OTTHUMP00000227599, OTTHUMP00000227600,

Application Dilution:
WB:1:1,000-1:2,000

Specificity: Angiopoietin 1 polyclonal antibody detects endogenous levels of Angiopoietin 1 protein.

Immunogen:
recombinant protein

MW: 57 kDa

Swiss-Prot: Q15389(Human) O35460(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.