Angiotensin II polyclonal, anti-human, mouse, rat
€422.00
In stock
SKU
251229
Catalog Nr.: 251229
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Datasheet
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Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Datasheet
Request Information
Protein Family: Hormones
Pathway and Disease: Signaling Molecules and Interaction, Endocrine System
Description:
Angiotensin II is an essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin I (angiotensin 1-10). Angiotensin I is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin II (angiotensin 1-8). Angiotensin II acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Genetic variations in angiotensin II are a cause of susceptibility to essential hypertension (EHT). Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause.
Alternate Names: Ang-II, Ang II, Angiotensin II, Angiotensin-2, AGT, Angiotensinogen, Serpin A8
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P01019
Antigen: KLH-conjugated MAP synthetic peptide corresponding to human angiotensinogen II.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Zhang H et al. 2017. J Neuroimmunol. PMID 29169800.
[2] Guo W et al. 2016. PLoS One. 11(4): e0153434. PMID 27073902.
[3] Wang C. et al. 2015. J Cardiovasc Pharmacol. 66(3):285-293. PMID 25955575.
[4] Wang C et al. 2015. Acta Biochim Biophys Sin. PMID 26071572.
[5] Matsuura-Hachiya Y et al. 2013. Biochem. Biophys. Res. Commun. 442(1-2):34-43. PMID 24216112.
Pathway and Disease: Signaling Molecules and Interaction, Endocrine System
Description:
Angiotensin II is an essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin I (angiotensin 1-10). Angiotensin I is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin II (angiotensin 1-8). Angiotensin II acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Genetic variations in angiotensin II are a cause of susceptibility to essential hypertension (EHT). Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause.
Alternate Names: Ang-II, Ang II, Angiotensin II, Angiotensin-2, AGT, Angiotensinogen, Serpin A8
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P01019
Antigen: KLH-conjugated MAP synthetic peptide corresponding to human angiotensinogen II.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Zhang H et al. 2017. J Neuroimmunol. PMID 29169800.
[2] Guo W et al. 2016. PLoS One. 11(4): e0153434. PMID 27073902.
[3] Wang C. et al. 2015. J Cardiovasc Pharmacol. 66(3):285-293. PMID 25955575.
[4] Wang C et al. 2015. Acta Biochim Biophys Sin. PMID 26071572.
[5] Matsuura-Hachiya Y et al. 2013. Biochem. Biophys. Res. Commun. 442(1-2):34-43. PMID 24216112.
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