Angiotensinogen Polyclonal Antibody

Background:
Angiotensinogen is a precursor of angiotensin II (Ang II), is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Research Area: Cancer, Cardiovascular, Metabolism, Signal Transduction

Synonyms:
Aangiotensinogen (serpin peptidase inhibitor clade A member 8), AGT, AI265500, Alpha 1 antiproteinase antitrypsin, Ang, Ang I, Ang II, Ang III, AngII, Angiotensin I, Angiotensin II, Angiotensin III, Angiotensin-3, Angiotensinogen (PAT), Angiotensinogen, ANGT, ANHU, ANRT, AT-2, AT-II, Des-Asp[1]-angiotensin II, PAT, Pre angiotensinogen, Serine (or cysteine) proteinase inhibitor, Serpin A8, Serpin peptidase inhibitor clade A member 8, SERPINA8

Immunogen: Recombinant Mouse Angiotensinogen protein

Swissprot: P11859
Gene ID: 183

Calculated MW: 52 kDa
Observed MW: 52 kDa

Purification Method: Antigen Affinity Purification

Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.

Concentration: 1mg/mL
Dilution:
WB 1:2000-1:5000
IHC 1:100-1:300

Storage:
Store at -20℃. Avoid freeze / thaw cycles.