ANGPTL3 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
ANGPTL3(Angiopoietin-Like 3), also known as ANGPT5, is a protein which in humans is encoded by the ANGPTL3 gene. The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. By radiation hybrid mapping and the use of surrounding genes, Conklin et al.(1999) mapped the ANGPTL3 gene to chromosome 1p31. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen(FBN)-like domain. Angptl3 also acts as dual inhibitor of lipoprotein lipase(LPL) and endothelial lipase(EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels.

Description:
Rabbit IgG polyclonal antibody for Angiopoietin-related protein 3 (ANGPTL3) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
ANG 5 antibody, ANG-5 antibody, ANG5 antibody, Angiopoietin 5 antibody, Angiopoietin like 3 antibody, Angiopoietin related protein 3 antibody, Angiopoietin-5 antibody, Angiopoietin-like protein 3 antibody, Angiopoietin-related protein 3 antibody, ANGL3_HUMAN antibody, ANGPT5 antibody, ANGPTL3 antibody, ANL3 antibody, FHBL2 antibody, OTTHUMP00000010719 antibody, UNQ153/PRO179 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human ANGPTL3(32-48aa EPKSRFAMLDDVKILAN), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human.
Predicted to work with: mouse, rat.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.