ANGPTL4 antibody (clone 1F7), anti-human
€435.00
In stock
SKU
AC-AT1138a
Catalog Number: AC-AT1138a
Size: 100 µg
Isotype: mouse IgG
Applications: E
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Size: 100 µg
Isotype: mouse IgG
Applications: E
Request Information AC-AT1138a">Request Information
Background:
This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4.
Other Names:
Angiopoietin-related protein 4, Angiopoietin-like protein 4, Hepatic fibrinogen/angiopoietin-related protein, HFARP, ANGPTL4, ARP4, HFARP, PGAR
Antigen Type:
Recombinant Protein
Gene Name: ANGPTL4
Gene ID: 51129
NCBI Accession: NP_001034756.1;NP_647475.1
Primary Accession: Q9BY76
Other Accession: BC023647
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4.
Other Names:
Angiopoietin-related protein 4, Angiopoietin-like protein 4, Hepatic fibrinogen/angiopoietin-related protein, HFARP, ANGPTL4, ARP4, HFARP, PGAR
Antigen Type:
Recombinant Protein
Gene Name: ANGPTL4
Gene ID: 51129
NCBI Accession: NP_001034756.1;NP_647475.1
Primary Accession: Q9BY76
Other Accession: BC023647
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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