Annexin A1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
ANXA1, also known as lipocortin I or Annexin A1, is a protein that in humans is encoded by the ANXA1 gene. It is mapped to 9q21.13. ANXA1 belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. ANXA1 protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Lower peptide concentrations possibly found in inflammatory situations elicit Ca(2+) transients without fully activating the mitogen-activated protein kinase pathway. This causes a specific inhibition of the transendothelial migration of neutrophils and a desensitization of neutrophils toward a chemoattractant challenge. These findings identified ANXA1 peptides as novel, endogenous FPR ligands and established a mechanistic basis of ANXA1-mediated antiinflammatory effects.

Description:
Rabbit IgG polyclonal antibody for Annexin A1 (ANXA1) detection. Tested with WB, IHC-P, IHC-F in Human, Mouse, Rat.

Synonyms:
Annexin 1 antibody, Annexin A1 antibody, Annexin I (lipocortin I) antibody, Annexin I antibody, Annexin-1 antibody, AnnexinA1 antibody, AnnexinI antibody, ANX 1 antibody, ANX A1 antibody, ANX1 antibody, ANXA 1 antibody, ANXA1 antibody, ANXA1 protein antibody, ANXA1_HUMAN antibody, Calpactin 2 antibody, Calpactin II antibody, Calpactin-2 antibody, CalpactinII antibody, Chromobindin 9 antibody, Chromobindin-9 antibody, Chromobindin9 antibody, Lipocortin 1 antibody, Lipocortin I antibody, Lipocortin1 antibody, LipocortinI antibody, LPC 1 antibody, LPC1 antibody, p35 antibody, Phospholipase A2 inhibitory protein antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Annexin A1 recombinant protein (Position: A2-N346). Human Annexin A1 shares 88% and 89% amino acid (aa) sequences identity with mouse and rat Annexin A1, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P, IHC-F

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.