EKLF polyclonal, anti-human
€470.00
In stock
SKU
AC-AP73608
Background:
Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
Other Names:
KLF1; EKLF; Krueppel-like factor 1; Erythroid krueppel-like transcription factor; EKLF
Antigen Type: synthetic peptide
Antigen Type: KLF1
Gene ID: 10661
Primary Accession: Q13351
Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
Other Names:
KLF1; EKLF; Krueppel-like factor 1; Erythroid krueppel-like transcription factor; EKLF
Antigen Type: synthetic peptide
Antigen Type: KLF1
Gene ID: 10661
Primary Accession: Q13351
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