Annexin A2 polyclonal, anti-human, mouse, rat

Background:
The annexin family of calcium-binding proteins is composed of at least ten mammalian genes and is characterized by a conserved core domain which binds phospholipids in a Ca2+-dependent manner and a unique amino-terminal region which may confer binding specificity. The interaction between these proteins and biological membranes has led to the hypothesis that they are involved in cellular trafficking processes such as endocytosis, exocytosis and cellular adhesion. Annexin I, alternatively referred to as lipocortin, has been implicated as a mediator of the anti-inflammatory response produced by glucocorticoids and as an inhibitor of cPLA2, a potent mediator of inflammation. Annexin II, also called p36, exists as a monomer or as a heterotetramer, complexed with the S-100-related protein p11. This complex is termed calpactin I. In the tetrameric form, Annexin II is an efficient substrate of PKC family and Src pp60.

Alternative Name:
PAP-IV, ANXA2, ANX2, ANX2L4, CAL1H, LPC2D, Annexin A2, Annexin II, Annexin II, heavy chain, Annexin-2, ANX 2, ANX2, ANX2L4, ANXA2, ANXA2, arylsulfatase B, CAL1H, Calpactin I heavy chain, calpactin I heavy polypeptide (p36), Calpactin I heavy polypeptide, Calpactin-1 heavy chain, chromobindin 8, Chromobindin-8, Epididymis secretory protein Li 270, HEL S 270, LIP2, Lipocortin II, LPC2, LPC2D, p36, P36 protein, PAP-IV, Placental anticoagulant protein IV, Protein I,

Application Dilution:
WB:1:500-1:2,000
IHC:1:50-1:200
ICC:1:100-1:200
FC:1:50-1:200

Specificity: Annexin A2 polyclonal antibody detects endogenous levels of Annexin A2 protein.

Immunogen:
recombinant protein

MW: 38 kDa

Swiss-Prot: P07355(Human) P07356(Mouse) Q07936(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.