Annexin VIII polyclonal, anti-rat, human

Quantity: 100 µg

Background:
Human Annexin A8 was originally identified from a 2-kb cDNA transcript containing an open reading frame that encoded a 327-amino acid protein termed vascular anticoagulant beta. It is a minor annexin in human placenta and shows restricted expression in lung endothelia, skin, liver, and kidney. The gene is selectively overexpressed in acute myelocytic leukemia. The Annexin A8 gene is mapped to chromosome 10q11.2 by fluorescence in situ hybridization. Affected human promyelocytes contain a nonrandom chromosomal translocation breakpoint involving chromosomes 15 and 17 and creating 2 hybrid mRNA fusion products and chimeric proteins. These involve the retinoic acid receptor-alpha geneon chromosome 17q12 and the promyelocytic leukemia gen on chromosome 15q22. Strong overexpression of Annexin A8 in this disorder could be repressed by retinoic acid-induced expression of the RARA gene product.

Description:
Rabbit IgG polyclonal antibody for Annexin A8 (ANXA8) detection. Tested with WB in Human, Rat.

Synonyms:
Annexin A8 antibody, Annexin VIII antibody, Annexin-8 antibody, ANX8 antibody, Anxa8 antibody, ANXA8_HUMAN antibody, VAC beta antibody, VAC-beta antibody, Vascular anticoagulant beta antibody, Vascular anticoagulant-beta antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human Annexin VIII(94-109aa PYRYEAKELHDAMKGL), different from the related mouse sequence by one amino acid.A synthetic peptide corresponding to a sequence in the middle region of human Annexin VIII(94-109aa PYRYEAKELHDAMKGL), different from the related mouse sequence by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: rat.
Predicted to work with: human.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.