ANO1 Polyclonal Antibody

Background:
TMEM16A, also known as DOG1, ORAOV2, TAOS2 or ANO1 (anoctamin 1), is a 986 amino acid multi-pass membrane protein that localizes to both the cell membrane and the cytoplasm and belongs to the anoctamin family. Expressed in a variety of tissues with highest expression in skeletal muscle and liver, TMEM16A functions as a calcium-activated chloride channel that is required for normal tracheal development. Human TMEM16A shares 90% sequence identity with its mouse counterpart, suggesting a conserved role between species. TMEM16A is present in breast, pancreatic, gastric, and uterine cancers, as well as in neck, ovarian and parathyroid tumors, suggesting a role for TMEM16A in carcinogenesis. Three isoforms of TMEM16A exist due to alternative splicing events.

Research Area: Cancer, Tags and Cell Markers

Synonyms:
ANO1, DOG1, ORAOV2, TAOS2, TMEM16A

Immunogen: Recombinant fusion protein of human ANO1 (NP_060513.5).

Swissprot: Q5XXA6
Gene ID: 55107

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IF 1:100-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.