Anti-CS1 antibody (DM9), Rabbit mAb
€473.00
In stock
SKU
DME100009
Background:
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
Synonyms: SLAM7 (19A, CD319, CRACC, CS1)
Host: Rabbit
Isotype: Rabbit IgG
Clonality: Monoclonal
Formulation: Human
Applications: ELISA, Flow Cyt, IP, IF
Recommended Dilutions: Flow Cyt 1/100
Purification: Purified from cell culture supernatant by affinity chromatography
Formulation: Liquid
Storage: Store at -20°C for 12 months (Avoid repeated freezing and thawing)
Usage: Research use only
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
Synonyms: SLAM7 (19A, CD319, CRACC, CS1)
Host: Rabbit
Isotype: Rabbit IgG
Clonality: Monoclonal
Formulation: Human
Applications: ELISA, Flow Cyt, IP, IF
Recommended Dilutions: Flow Cyt 1/100
Purification: Purified from cell culture supernatant by affinity chromatography
Formulation: Liquid
Storage: Store at -20°C for 12 months (Avoid repeated freezing and thawing)
Usage: Research use only
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