ANTXR1 polyclonal, anti-human, mouse

Background:
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

Synonyms: ATR, GAPO, TEM8

Cellular Location: Cell membrane Cell projection Single-pass type I membrane protein filopodium membrane lamellipodium membrane

Immunogen:
Recombinant protein of human ANTXR1

Gene Symbol: ANTXR1

Gene ID: 84168

Swiss prot: Q9H6X2

Calculated MW: 63kDa

Recommended dilution:
WB 1:500-2000, IF 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.