APC antibody (clone 300), anti-human

Background:
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Other Names:
Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 25, APC, DP25

Antigen Type:
Recombinant Protein

Gene Name: APC (HGNC:583)
Gene ID: 324
NCBI Accession: NP_000029.2;NP_001120982.1
Primary Accession: P25054
Other Accession: NM_000038
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .