APEH Polyclonal Antibody

Background:
This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma.

Research Area: Cancer, Cell Biology

Synonyms:
AARE, ACPH, ACPH, Acyl peptide hydrolase, Acyl-peptide hydrolase, Acylamino acid releasing enzyme, Acylamino-acid-releasing enzyme, Acylaminoacyl peptidase, Acylaminoacyl-peptidase, APEH, APH, N acylaminoacyl peptide hydrolase, OPH, Oxidized protein hydrolase

Immunogen: Synthetic peptide of human APEH

Swissprot: P13798
Gene Accession: NP_001631

Calculated MW: 81 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.3 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-102310/sc-102311/sc-102312