APEX1 polyclonal, anti-human

Background:
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

Synonyms: APE, APE1, APEN, APEX, APX, HAP1, REF1

Cellular Location: Cytoplasm Endoplasmic reticulum Mitochondrion Nucleus Nucleus speckle nucleolus

Immunogen:
Recombinant protein of human APEX1

Gene Symbol: APEX1

Gene ID: 328

Swiss prot: P27695

Calculated MW: 36kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-100, IF 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.