APG1 (ULK1) polyclonal (Center), anti-human
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In stock
SKU
AC-AP8104d
Catalog Number: AC-AP8104d
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB13255
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB13255
Applications: WB
Datasheet
Request Information
Background:
Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Two human homologs of the yeast autophagy-specific kinase exist: ULK1(APG1) and ULK2. APG1 plays a critical role in regulating key elements of the autophagy pathway. APG1 stimulates autophagy, leading to autophagy-dependent restriction of cell growth and ultimately cell apoptosis at high levels of activity, and is a negative regulator of mTOR signaling.
Other Names:
Serine/threonine-protein kinase ULK1, Autophagy-related protein 1 homolog, ATG1, hATG1, Unc-51-like kinase 1, ULK1, KIAA0722
Target/Specificity:
This APG1 (ULK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 670~700 amino acids from the Center region of human ULK1.
Antigen Region:
670-700
Antigen Type: Synthetic Peptide
Gene Name: ULK1 {ECO:0000303|PubMed:9693035, ECO:0000312|HGNC:HGNC:12558}
Gene ID: 8408
Primary Accession: O75385
NCBI Accession: NP_003556.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Two human homologs of the yeast autophagy-specific kinase exist: ULK1(APG1) and ULK2. APG1 plays a critical role in regulating key elements of the autophagy pathway. APG1 stimulates autophagy, leading to autophagy-dependent restriction of cell growth and ultimately cell apoptosis at high levels of activity, and is a negative regulator of mTOR signaling.
Other Names:
Serine/threonine-protein kinase ULK1, Autophagy-related protein 1 homolog, ATG1, hATG1, Unc-51-like kinase 1, ULK1, KIAA0722
Target/Specificity:
This APG1 (ULK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 670~700 amino acids from the Center region of human ULK1.
Antigen Region:
670-700
Antigen Type: Synthetic Peptide
Gene Name: ULK1 {ECO:0000303|PubMed:9693035, ECO:0000312|HGNC:HGNC:12558}
Gene ID: 8408
Primary Accession: O75385
NCBI Accession: NP_003556.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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