APG12/ATG12 polyclonal, anti-human, mouse, rat antibody
€275.00
In stock
SKU
AC-ABV10706-100
Catalog Number: AC-ABV10706-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
Autophagy, the process of bulk degradation of cellular proteins thro µgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) thro µgh phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conj µgate with ATG5, this conj µgate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conj µgate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist.
Other Names:
APG12 , APG12L , ATG12 , HAPG12
Primary Accession: Q9CQY1
Gene Name: Atg12
Gene ID: 67526
Concentration (mg/ml): 0.5 mg/ml
Autophagy, the process of bulk degradation of cellular proteins thro µgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) thro µgh phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conj µgate with ATG5, this conj µgate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conj µgate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist.
Other Names:
APG12 , APG12L , ATG12 , HAPG12
Primary Accession: Q9CQY1
Gene Name: Atg12
Gene ID: 67526
Concentration (mg/ml): 0.5 mg/ml
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