APG16/ATG16 polyclonal, anti-human, mouse, rat antibody
€275.00
In stock
SKU
AC-ABV10707-100
Catalog Number: AC-ABV10707-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
Autophagy, the process of bulk degradation of cellular proteins thro µgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) thro µgh phosphorylation of autophagy protein APG1. ATG16, another member of the autophagy protein family, forms a complex with the ATG5-ATG12 conj µgate. This multimeric protein has been shown to be essential for autophagosome formation in both yeast and mammals and targets the ATG5-ATG12 complex to the autophagic isolation membrane during the formation of the autophagosome. Because mammalian ATG16 has seven WD-repeats in its C-terminal domain, it has been s µggested that these may form a platform for further protein-protein interactions. Multiple isoforms of ATG16 are known to exist.
Other Names:
APG16 , APTG 16
Primary Accession: Q676U5
Gene Name: ATG16L1
Gene ID: 55054
Concentration (mg/ml): 0.5 mg/ml
Autophagy, the process of bulk degradation of cellular proteins thro µgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) thro µgh phosphorylation of autophagy protein APG1. ATG16, another member of the autophagy protein family, forms a complex with the ATG5-ATG12 conj µgate. This multimeric protein has been shown to be essential for autophagosome formation in both yeast and mammals and targets the ATG5-ATG12 complex to the autophagic isolation membrane during the formation of the autophagosome. Because mammalian ATG16 has seven WD-repeats in its C-terminal domain, it has been s µggested that these may form a platform for further protein-protein interactions. Multiple isoforms of ATG16 are known to exist.
Other Names:
APG16 , APTG 16
Primary Accession: Q676U5
Gene Name: ATG16L1
Gene ID: 55054
Concentration (mg/ml): 0.5 mg/ml
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