Apg3 (Atg3) monoclonal, anti-human, mouse, rat
€455.00
In stock
SKU
AC-ABO14107
Catalog Number: AC-ABO14107
Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IHC, IF, ICC
Datasheet
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Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IHC, IF, ICC
Datasheet
Request Information
Description: Anti-Apg3 (Atg3) Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Protein Function:
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12- ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway..
Other Names: Ubiquitin-like-conjugating enzyme ATG3, 2.3.2.-, Autophagy-related protein 3, APG3-like, hApg3, Protein PC3-96 {ECO:0000305|Ref.2}, ATG3 (HGNC:20962), APG3, APG3L
Clone Name(s):
Clone: ABBC-1
Subcellular Localization: Cytoplasm.
Tissue Specificity: Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta..
Gene ID: 64422
Immunogen: A synthesized peptide derived from human Apg3 (Atg3)
Calculated MW: 35864
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Function:
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12- ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway..
Other Names: Ubiquitin-like-conjugating enzyme ATG3, 2.3.2.-, Autophagy-related protein 3, APG3-like, hApg3, Protein PC3-96 {ECO:0000305|Ref.2}, ATG3 (HGNC:20962), APG3, APG3L
Clone Name(s):
Clone: ABBC-1
Subcellular Localization: Cytoplasm.
Tissue Specificity: Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta..
Gene ID: 64422
Immunogen: A synthesized peptide derived from human Apg3 (Atg3)
Calculated MW: 35864
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
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