APG7/ATG7 polyclonal, anti-human, mouse antibody
€275.00
In stock
SKU
AC-ABV10703-100
Catalog Number: AC-ABV10703-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
Autophagy, the process of bulk degradation of cellular proteins thro µgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) thro µgh phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is APG7 which was identified in yeast as a ubiquitin-E1-like enzyme, this function is conserved in the mammalian homolog (4). In mammalian cells, APG7 is essential for autophagy conj µgation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles. It has been s µggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death.
Other Names:
APG7L , ATG7 , DKFZp434N0735 , GSA7
Primary Accession: Q641Y5
Other Accession: NP_001012097
Gene Name: Atg7
Gene ID: 312647
Concentration (mg/ml): 0.5 mg/ml
Autophagy, the process of bulk degradation of cellular proteins thro µgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) thro µgh phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is APG7 which was identified in yeast as a ubiquitin-E1-like enzyme, this function is conserved in the mammalian homolog (4). In mammalian cells, APG7 is essential for autophagy conj µgation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles. It has been s µggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death.
Other Names:
APG7L , ATG7 , DKFZp434N0735 , GSA7
Primary Accession: Q641Y5
Other Accession: NP_001012097
Gene Name: Atg7
Gene ID: 312647
Concentration (mg/ml): 0.5 mg/ml
| Is Featured? | No |
|---|
Write Your Own Review