APH1 polyclonal (N-term), anti-human
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In stock
SKU
AC-AP6302A
Catalog Number: AC-AP6302A
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB4994
Applications: WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB4994
Applications: WB, IHC-P
Datasheet
Request Information
Background:
APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2, although other components may exist. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
Other Names:
Gamma-secretase subunit APH-1A, APH-1a, Aph-1alpha, Presenilin-stabilization factor, APH1A, PSF
Target/Specificity:
This APH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-109 amino acids from the N-terminal region of human APH1.
Antigen Region:
77-109
Antigen Type: Synthetic Peptide
Gene Name: APH1A
Gene ID: 51107
Primary Accession: Q96BI3
NCBI Accession: NP_001071096.1;NP_001230700.1;NP_001230701.1;NP_057106.2
Other Accession: Q8BVF7
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2, although other components may exist. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
Other Names:
Gamma-secretase subunit APH-1A, APH-1a, Aph-1alpha, Presenilin-stabilization factor, APH1A, PSF
Target/Specificity:
This APH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-109 amino acids from the N-terminal region of human APH1.
Antigen Region:
77-109
Antigen Type: Synthetic Peptide
Gene Name: APH1A
Gene ID: 51107
Primary Accession: Q96BI3
NCBI Accession: NP_001071096.1;NP_001230700.1;NP_001230701.1;NP_057106.2
Other Accession: Q8BVF7
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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