APIP polyclonal, anti-human, mouse

Background:
APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury.The protein highly expressed in skeletal muscle and heart and binds to the CARD of Apaf-1 in competition with caspase-9. Exogenous APIP inhibits cytochrome c-induced activation of caspase-3 and caspase-9, and suppresses cell death triggered by mitochondrial apoptotic stimuli through inhibiting the downstream activity of cytochrome c released from mitochondria.

Synonyms: APIP2, CGI29, CGI-29, MMRP19, dJ179L10.2

Cellular Location: Cytoplasm Nucleus

Immunogen:
Recombinant protein of human APIP

Gene Symbol: APIP

Gene ID: 51074

Swiss prot: Q96GX9

Calculated MW: 27kDa

Recommended dilution:
WB 1:200-1000, IHC 1:25-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.