APLP1 polyclonal, anti-human, mouse, rat

Background:
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.

Alternative Name:
Amyloid-like protein 1 precursor, APLP 1, APLP, APLP-1, Aplp1, APLP1_HUMAN, C30

Application Dilution:
WB: 1:500~1:2000
IHC: 1:50~1:200

Specificity: APLP1 polyclonal antibody detects endogenous levels of APLP1 protein.

Immunogen:
Recombinant full length Human APLP1.

MW: ~72 kDa

Swiss-Prot: P51693

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.