APOA1 Polyclonal Antibody

Background:
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein.

Research Area: Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction

Synonyms:
APOA1, apo(a)

Immunogen: Recombinant fusion protein of human APOA1 (NP_000030.1).

Swissprot: P02647
Gene ID: 335

Calculated MW: 30 kDa
Observed MW: 31 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:100 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.