APOC1 rabbit polyclonal, anti-human, mouse, rat

Backgroud: This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016],function:Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein.,miscellaneous:Apo-CI makes up about 10% of the protein of the VLDL (very low density lipoprotein) and 2% of that of HDL (high density lipoprotein).,online information:Apolipoprotein C1 entry,similarity:Belongs to the apolipoprotein C1 family.,tissue specificity:Synthesized mainly in liver and to a minor degree in intestine. Secreted in plasma.,

Synonyms: Apolipoprotein C-I (Apo-CIB, ApoC-IB, Apolipoprotein C1) [Cleaved into: Truncated apolipoprotein C-I (Apo-CIB', ApoC-IB')]

Gene Name: APOC1 APOC1B

Gene ID: 341

SwissProt ID: P02654

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.