ApoER2 polyclonal, anti-human, mouse

Background:
ApoER2 (apolipoprotein E receptor 2), also designated LRP8, is a member of the LDL receptor gene family, which includes LDL receptor, LRP, megalin, VLDLR and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. ApoER2 is expressed in brain and placenta and has several splice variants. ApoER2 is thought to mediate the interaction of extracellular Reelin and cytosolic mDab1 (mammalian disabled protein), which activates a tyrosine kinase. This pathway regulates the migration of neurons along the radial glial fiber network during brain development.

Alternative Name:
LRP-8, LRP8, APOER2, APOER2, Apolipoprotein E receptor 2, low density lipoprotein receptor-related protein 8, Low-density lipoprotein receptor-related protein 8, LRP-8, LRP8, LRP8,

Application Dilution:
WB:1:500-1:1,000
ICC:1:50-1:200
IHC:1:50
FC:1:50-1:100

Specificity: ApoER2 polyclonal antibody detects endogenous levels of ApoER2 protein.

Immunogen:
Recombinant protein within human ApoER2 500-750 aa.

MW: 77 kDa

Swiss-Prot: Q14114(Human) Q924X6(Mouse)

Purification & Purity:
Protein affinity purified.

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.