Apolipoprotein A I polyclonal, anti-rat

Quantity: 100 µg

Background:
Apolipoprotein A-1, also known as APOA1, is a human protein with a specific role in lipid metabolism. It binds to lipopolysaccharide or endotoxin, and has a major role in the anti-endotoxin function of HDL. The gene is mapped to 11q23. And it is a single polypeptide chain with 243 amino acid residues of known primary amino acid sequence. The ApoA-I protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. ApoA-I is also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Additionally, ApoA-I overexpression promotes macrophage-specific reverse cholesterol transport.

Description:
Rabbit IgG polyclonal antibody for Apolipoprotein A-I (APOA1) detection. Tested with WB, IHC-P in Rat.

Synonyms:
Apo AI antibody, Apo-AI antibody, ApoA I antibody, ApoA-I antibody, APOA1 antibody, APOA1/APOC3 fusion gene antibody, APOA1_HUMAN antibody, Apolipoprotein A I precursor antibody, Apolipoprotein A-I(1-242) antibody, Apolipoprotein A1 antibody, Apolipoprotein AI antibody, Apolipoprotein of high density lipoprotein antibody, ApolipoproteinAI antibody, Brp14 antibody, Ltw1 antibody, Lvtw1 antibody, MGC117399 antibody, Sep1 antibody, Sep2 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E. coli-derived rat Apolipoprotein A I recombinant protein (Position: D25-A259). Rat Apolipoprotein A I shares 61.7% and 68.6% amino acid (aa) sequence identity with human and mouse Apolipoprotein A I, respectively.E. coli-derived rat Apolipoprotein A I recombinant protein (Position: D25-A259). Rat Apolipoprotein A I shares 61.7% and 68.6% amino acid (aa) sequence identity with human and mouse Apolipoprotein A I, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.