AR Polyclonal Antibody

Background:
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Developmental Biology, Signal Transduction

Synonyms:
AIS, ANDR, Androgen nuclear receptor variant 2, Androgen receptor (dihydrotestosterone receptor, testicular feminization, spinal and bulbar muscular atrophy, Kennedy disease), Androgen receptor, androgen receptor splice variant 4b, AR, AR8, DHTR, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), Dihydrotestosterone receptor, HUMARA, HYSP1, KD, Kennedy disease (KD), NR3C4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Nuclear receptor subfamily 3 group C member 4, SBMA, SMAX1, Spinal and bulbar muscular atrophy (SBMA), Spinal and bulbar muscular atrophy, Testicular Feminization (TFM), TFM

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Androgen receptor

Swissprot: P10275;P19091;P15207

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 0.83 mg/mL
Dilution: IHC 1:300-1:1000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.