ARC Polyclonal Antibody

Background:
Arc (for activity-regulated cytoskeleton-associated protein) is a growth factor and immediate early gene that is enriched in brain. Arc mRNA and protein levels are induced by neuronal activity, which is necessary to stimulate neuroplasticity, indicating a potential role for Arc in activity-dependent changes in dendrite function. Arc expression has been detected in neuronal cell bodies and dendrites in the hippocampus, amygdala, hypothalamus, striatum and cortex. Arc has been shown to localize to the cytoskeleton of neuronal cells and appears to colocalize with F-Actin, although it may associate with an Actin-associated protein rather than directly with F-Actin. It has been shown that cocaine-stimulated neuronal activity results in increased Arc mRNA levels in striatum.

Research Area: Cancer, Neuroscience

Synonyms:
activity regulated cytoskeleton associated protein, activity regulated gene 3.1 protein homolog, Activity-regulated cytoskeleton-associated protein, Activity-regulated gene 3.1 protein homolog, Arc, ARC/ARG3.1, ARC, Arg3.1

Immunogen: Recombinant protein of human ARC

Swissprot: Q7LC44
Gene Accession: BC012321

Calculated MW: 45 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-33947/sc-6381/sc-6382/sc-15325