ARG2 Polyclonal Antibody

Background:
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4+ and CD8+ T cells (PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082).

Research Area: Cancer, Metabolism, Signaling transduction

Synonyms:
ARG2, ARGI2, Arginase II mitochondrial, Arginase type II, Arginase-2, arginase-2, mitochondrial, Kidney arginase, Kidney type arginase, Kidney-type arginase, L arginine amidinohydrolase, L arginine ureahydrolase, mitochondrial, Non hepatic arginase, Non-hepatic arginase, Nonhepatic arginase, Type II arginase

Immunogen: Recombinant human Arginase-2 protein

Swissprot: P78540

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 2 mg/mL
Dilution: IHC 1:50-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.