Arginase 1 (Hepatocellular Carcinoma Marker) (clone ARG1/1126 ), anti-human

Background:
Recognizes a protein of 35-38kDa, which is identified as Arginase 1 (ARG1). Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Arginase I and II are isoenzymes, which differ in subcellular localization, regulation, and possibly function. Arginase I is a cytosolic enzyme, which is expressed mainly in the liver as part of the urea cycle, whereas arginase II is a mitochondrial protein found in a variety of tissues. Antibody to ARG-1 labels hepatocytes in normal tissues and granulocytes in peripheral blood. ARG-1 is a sensitive and specific marker for identification of hepatocellular carcinoma.

Other Names:
Arginase-1, 3.5.3.1, Liver-type arginase, Type I arginase, ARG1

Gene Name: ARG1
Gene ID: 383
Primary Accession: P05089
Other Accession: 383, 440934