ARHGDIB Polyclonal Antibody

Background:
ARHGDIB, also known as RhoGDI2, is a conserved member of the RhoGDI family and plays an important role in cell migrations. It regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
It is mainly in hematopoietic, endothelial, and epithelial cells. It has been linked to tumorigenesis and metastasis. RhoGDI2 expression is downregulated in several cancer types, such as bladder, lung and lymphoma, but is upregulated in prostate and gastric cancer.

Research Area: Cancer, Signal Transduction

Synonyms:
Arhgdib, D4, D4 GDP dissociation inhibitor, GDIA 2, GDIA2, GDID 4, GDID4, GDIR2, GDP dissociation inhibitor D4, LY GDI, Ly-GDI, LYGDI, MGC108926, RAP1GN1, Rho GDI 2, Rho GDI beta, Rho GDI2, Rho GDP dissociation inhibitor (GDI) beta, Rho GDP dissociation inhibitor 2, Rho GDP dissociation inhibitor beta, Rho GDP-dissociation inhibitor 2, Rho-GDI beta, RhoGDI2

Immunogen: Synthetic peptide of human ARHGDIB

Swissprot: P52566
Gene Accession: NP001166

Calculated MW: 23 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.